The Agoro Lab: Redox Systems Biology Laboratory
The Agoro lab uses systems biology approaches to determine how iron-driven kidney oxidative stress influences FGF23-mediated phosphate excretion in aging, chronic kidney disease and sickle cell anemia.
In aged or diseased states, changes in cellular iron metabolism occur in the kidney driving therefore oxidative stress and renal function impairment. One consequence is the decrease of the ability of the kidney to get rid of phosphate from the blood and thus the body could not prevent detrimental outcomes such as vascular calcification. Our lab is dedicated to study the mechanisms associated with renal iron handling during physiological and pathological states and how these mechanisms influence the kidney ability to excrete phosphate.